Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.59 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.59 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22481605 | 0.85 | NOTUM (0.74) | NOTUMCYP2C19CYP2C9L3MBTL1TDP1 | |
| SCHEMBL22481505 | 0.84 | NOTUM (0.72) | NOTUMCYP2C19CYP2C9L3MBTL1TDP1 | |
| SCHEMBL1544352 | 0.84 | NOTUM (0.72) | NOTUMCYP2C19CYP2C9L3MBTL1TDP1 | |
| SCHEMBL3989816 | 0.82 | NOTUM (0.70) | NOTUMCYP2C19CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL2900978 | 0.81 | NOTUM (1.00) | NOTUMCYP2C19CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL5744065 | 0.81 | NOTUM (0.68) | NOTUMCYP2C19CYP2C9L3MBTL1TDP1 | |
| SCHEMBL2123479 | 0.81 | NOTUM (1.00) | NOTUMCYP2C19CYP2C9CYP2E1CYP2A6 | |
| SCHEMBL4945191 | 0.80 | NOTUM (0.67) | NOTUMCYP2C19CYP2C9L3MBTL1TDP1 | |
| SCHEMBL27788409 | 0.79 | NOTUM (0.65) | NOTUMCYP2C19CYP2C9L3MBTL1TDP1 | |
| SCHEMBL3988491 | 0.78 | NOTUM (0.64) | NOTUMCYP2C19CYP2C9CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| EP-3843844-A1 | COMPOUNDS | UCL Business Ltd (GB) | 2021-07-07 | — | — | EP | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
| WO-2020043866-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2020-03-05 | — | — | WO | disclosed |
| US-7790759-B2 | Glycyrrhetinic acid-30-amide derivatives and their use | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2010-09-07 | — | — | US | disclosed |
| EP-1935892-B1 | GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF | TIANJIN INST PHARM RESEARCH (CN) | 2010-08-11 | — | — | EP | disclosed |
| US-20080214636-A1 | Glycyrrhetinic Acid-30-Amide Derivatives and Their Use | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2008-09-04 | — | — | US | disclosed |
| EP-1935892-A1 | GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | NOTUM 1/4885CYP2C19 4347/4885CYP2C9 4595/4885 |
| US-20210171475-A1 | COMPOUNDS | GOT2, GOT1, OAT | NOTUM 5/4885CYP2C19 4252/4885CYP2C9 4500/4885 |
| US-20080214636-A1 | Glycyrrhetinic Acid-30-Amide Derivatives and Their Use | IL36G, CYP26A1, IL17A | NOTUM 2772/4885CYP2C19 42/4885CYP2C9 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.