Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.56 |
| ▸ | ARG2 | P78540 | 4/20 | 0.37 |
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | NOS2 | P35228 | 5/20 | 0.37 |
| ▸ | NOS1 | P29475 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL28275584 | 0.93 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL3312740 | 0.91 | GSR (0.62) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL3312731 | 0.91 | GSR (0.62) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL7113294 | 0.91 | GSR (0.67) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL20530995 | 0.91 | GSR (0.67) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL7113285 | 0.91 | GSR (0.67) | GSRARG2ARG1NOS2NOS1 | |
| Ornithine Aketoglutarate SCHEMBL29232510 | 0.87 | GSR (0.58) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL11327123 | 0.85 | GSR (0.77) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28944838 | 0.85 | GSR (0.77) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL28033142 | 0.85 | GSR (0.77) | GSRARG2ARG1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116535300-A | Method for catalyzing 5-chloro-2-pentanone to generate cyclopropyl methyl ketone by eutectic solvent | 中国科学院山西煤炭化学研究所 | 2023-08-04 | — | — | CN | disclosed |