Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.65 |
| ▸ | ARG2 | P78540 | 4/20 | 0.42 |
| ▸ | ARG1 | P05089 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 5/20 | 0.41 |
| ▸ | NOS1 | P29475 | 4/20 | 0.41 |
| ▸ | NOS3 | P29474 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL3312731 | 0.98 | GSR (0.62) | GSRARG2ARG1CYP3A4SLC5A7 | |
| Lysine SCHEMBL3312740 | 0.98 | GSR (0.62) | GSRARG2ARG1CYP3A4SLC5A7 | |
| Lysine SCHEMBL7113294 | 0.98 | GSR (0.67) | GSRARG2ARG1CYP3A4NOS2 | |
| Lysine SCHEMBL20530995 | 0.98 | GSR (0.67) | GSRARG2ARG1CYP3A4NOS2 | |
| Lysine SCHEMBL7113285 | 0.98 | GSR (0.67) | GSRARG2ARG1CYP3A4NOS2 | |
| Ornithine Aketoglutarate SCHEMBL29232510 | 0.93 | GSR (0.58) | GSRARG2ARG1CYP3A4SLC5A7 | |
| Lysine SCHEMBL29066022 | 0.93 | GSR (0.56) | GSRARG2ARG1CYP3A4SLC5A7 | |
| Lysine SCHEMBL28189329 | 0.91 | GSR (0.57) | GSRARG2ARG1CYP3A4NOS2 | |
| Lysine SCHEMBL28189328 | 0.91 | GSR (0.57) | GSRARG2ARG1CYP3A4NOS2 | |
| Lysine SCHEMBL28084777 | 0.90 | GSR (0.53) | GSRARG2ARG1CYP3A4NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110760449-B | Geotrichum galactose ZJPH1810 and application thereof in preparation of (S) -1- (2, 6-dichloro-3-fluorophenyl) ethanol | 浙江工业大学 | 2021-04-06 | — | — | CN | claimed |
| CN-110760449-A | Geotrichum galactose ZJPH1810 and application thereof in preparation of (S) -1- (2, 6-dichloro-3-fluorophenyl) ethanol | 浙江工业大学 | 2020-02-07 | — | — | CN | claimed |
| CN-112176019-B | Method for preparing (R) -1- (3-trifluoromethylphenyl) ethanol by biological catalysis | 浙江工业大学 | 2022-03-18 | — | — | CN | disclosed |
| CN-112176019-A | Method for preparing (R) -1- (3-trifluoromethylphenyl) ethanol by biological catalysis | 浙江工业大学 | 2021-01-05 | — | — | CN | disclosed |
| CN-109349422-A | A kind of piggy shifts to an earlier date feed for weaned and its application method | 靖西市聚隆生猪养殖场 | 2019-02-19 | — | — | CN | disclosed |