SCHEMBL2906810

SCHEMBL2906810

Cc1cc(OC(C)(C)C(=O)O)c(C)cc1OCCCCN(C)c1nc(-c2ccc(C(F)(F)F)cc2)cs1

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 12/20 0.46
PPARA Q07869 10/20 0.46
PPARG P37231 7/20 0.46
ALDH1A1 P00352 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
GSTO1 P78417 1/20 0.41
ATP4A P20648 2/20 0.40
ATP4B P51164 2/20 0.40
LTB4R Q15722 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
ALOX5 P09917 1/20 0.39
PSEN1 P49768 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2901229 0.97 PPARD (0.47) PPARDPPARAPPARGALDH1A1L3MBTL1
SCHEMBL2901332 0.95 PPARD (0.49) PPARDPPARAPPARGALDH1A1L3MBTL1
SCHEMBL2904547 0.89 PPARD (0.48) PPARDPPARAPPARGMEN1KMT2A
SCHEMBL2901188 0.89 RAB9A (0.46) PPARDPPARAALDH1A1L3MBTL1GSTO1
SCHEMBL2907616 0.88 TRPA1 (0.41) PPARDPPARAPPARGALDH1A1L3MBTL1
SCHEMBL2904008 0.87 KMT2A (0.50) PPARDPPARAALDH1A1L3MBTL1MEN1
SCHEMBL2900889 0.87 PPARD (0.46) PPARDPPARAPPARGALDH1A1L3MBTL1
SCHEMBL2903759 0.86 PPARD (0.49) PPARDPPARAPPARGMEN1KMT2A
SCHEMBL2906321 0.86 ALDH1A1 (0.43) PPARDPPARAPPARGALDH1A1L3MBTL1
SCHEMBL2903628 0.86 PPARD (0.57) PPARDPPARAPPARGATP4AATP4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1951692-B1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2010-08-18 EP claimed
US-20100048453-A1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2010-02-25 US claimed
EP-1951692-A1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2008-08-06 EP claimed
WO-2007056496-A1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2007-05-18 WO claimed
EP-1951692-B1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2010-08-18 EP disclosed
US-20100048453-A1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2010-02-25 US disclosed
US-20100048453-A1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2010-02-25 US disclosed
EP-1951692-A1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2008-08-06 EP disclosed
WO-2007056496-A1 OXAZOLE AND THIAZOLE PPAR MODULATOR IRM LLC (BM) 2007-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048453-A1 OXAZOLE AND THIAZOLE PPAR MODULATOR PPARD, PPARG, PPARA PPARD 1/4885PPARA 3/4885PPARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.