⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29182099 | 0.80 | ALDH1A1 (0.41) | — | |
| SCHEMBL7260805 | 0.80 | LMNA (0.34) | — | |
| SCHEMBL16774676 | 0.78 | — | — | |
| SCHEMBL36575 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL1007846 | 0.74 | — | — | |
| SCHEMBL5345997 | 0.74 | — | — | |
| SCHEMBL5345989 | 0.74 | — | — | |
| SCHEMBL16296076 | 0.71 | — | — | |
| SCHEMBL9254062 | 0.71 | — | — | |
| SCHEMBL548609 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108822180-A | A kind of 11- deoxy-glycyrrhetinic acid derivative and its preparation method and application | 广东工业大学 | 2018-11-16 | — | — | CN | disclosed |
| US-20160115542-A1 | BIOMARKER OF Nrf2 ACTIVATION | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2016-04-28 | — | — | US | disclosed |
| US-8969395-B2 | Triterpenoid derivatives useful as antiproliferative agents | UNIVERSIDADE DE COIMBRA (PT) | 2015-03-03 | — | — | US | disclosed |
| US-8969395-B2 | Triterpenoid derivatives useful as antiproliferative agents | UNIVERSIDADE DE COIMBRA (PT) | 2015-03-03 | — | — | US | disclosed |
| US-20120129901-A1 | TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | UNIVERSIDADE DE COIMBRA (PT) | 2012-05-24 | — | — | US | disclosed |
| US-20120129901-A1 | TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | UNIVERSIDADE DE COIMBRA (PT) | 2012-05-24 | — | — | US | disclosed |
| WO-2010134830-A1 | TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS | UNIVERSIDADE DE COIMBRA (PT) | 2010-11-25 | — | — | WO | disclosed |
| US-7825253-B2 | 2-aminoquinoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-2076495-B1 | QUINOLINE DERIVATIVES WITH 5-HT-BINDING PROPERTIES | HOFFMANN LA ROCHE (CH) | 2010-08-18 | — | — | EP | disclosed |
| US-20080081907-A1 | 2-AMINOQUINOLINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2008-04-03 | — | — | US | disclosed |
| US-20030181479-A1 | Substituted imidazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2003-09-25 | — | — | US | disclosed |
| US-6605634-B2 | Tumor necrosis factor alpha and interleukin-1 (IL-1) mediated diseases; pain, diabetes; cyclooxygenase inhibition | AMGEN, INC. | 2003-08-12 | — | — | US | disclosed |
| US-20030096819-A1 | Aryl and heteroaryl substituted fused pyrrole anti-inflammatory agents | AMGEN INC. | 2003-05-22 | — | — | US | disclosed |
| WO-2003040106-A1 | PREPARATION AND USE OF SUBSTITUTED IMIDAZOLES | NOVO NORDISK A/S (DK) | 2003-05-15 | — | — | WO | disclosed |
| US-6440973-B1 | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents | AMGEN INC. | 2002-08-27 | — | — | US | disclosed |
| US-6180643-B1 | ANTAGONIST OF INTERLEUKINS, TUMOR NECROSIS FACTOR | AMGEN INC. | 2001-01-30 | — | — | US | disclosed |
| CN-1246856-A | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |
| EP-0948495-A1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | Amgen Inc., (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998022457-A9 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | — | 1998-08-20 | — | — | WO | disclosed |
| WO-1998022457-A1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | AMGEN INC. (US) | 1998-05-28 | — | — | WO | disclosed |