Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.59 |
| ▸ | DHFR | P00374 | 7/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | ATR | Q13535 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30826811 | 1.00 | CDK1 (0.62) | CDK1CDK2JAK2CAMK2DDHFR | |
| SCHEMBL4466816 | 0.85 | CDK1 (0.66) | CDK1CDK2JAK2PIK3CAPIK3CD | |
| SCHEMBL3760144 | 0.84 | CAMK2D (0.65) | CDK1CDK2JAK2CAMK2DPIK3CA | |
| SCHEMBL29383512 | 0.82 | CDK1 (0.57) | CDK1CDK2JAK2CAMK2DDHFR | |
| SCHEMBL4611806 | 0.78 | DHFR (0.71) | DHFRPIK3CA | |
| SCHEMBL22801126 | 0.77 | MAPK14 (0.54) | JAK2CAMK2DDHFRATR | |
| SCHEMBL12801112 | 0.77 | JAK2 (1.00) | JAK2CAMK2DMAPK8MAPK10 | |
| SCHEMBL14961828 | 0.76 | DHFR (0.54) | CAMK2DDHFRPIK3CAPIK3CDPIK3CB | |
| SCHEMBL4033705 | 0.76 | PIM1 (0.67) | CDK1CDK2JAK2PIK3CAMAPK10 | |
| SCHEMBL14072025 | 0.76 | AGXT (0.51) | JAK2CAMK2DDHFRPIK3CAMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222682-A1 | IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009070516-A1 | IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-06-04 | — | — | WO | disclosed |