Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.58 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 11/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | ADK | P55263 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332294 | 0.86 | RAB9A (0.59) | CDK1CDK2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL30826811 | 0.85 | CDK1 (0.62) | CDK1CDK2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL2908002 | 0.85 | CDK1 (0.62) | CDK1CDK2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL30570935 | 0.84 | HRH4 (0.59) | CDK1CDK2RAB9ANPC1KDM4E | |
| SCHEMBL29383512 | 0.83 | CDK1 (0.57) | CDK1CDK2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL28446714 | 0.82 | JAK2 (0.55) | PIK3CDPIK3R1PIK3CAPIK3CBRAB9A | |
| SCHEMBL4033705 | 0.81 | PIM1 (0.67) | CDK1CDK2PIK3CDPIK3R1PIK3CA | |
| SCHEMBL4383881 | 0.78 | JAK2 (0.78) | JAK2JAK3HDAC3NCOR1JAK1 | |
| SCHEMBL3725617 | 0.78 | PIK3CA (0.72) | CDK2PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL7925159 | 0.78 | PIK3CA (0.59) | CDK1CDK2PIK3CDPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | claimed |
| CN-103483345-A | Phosphoinositide 3-kinase (P13K) inhibitor, pharmaceutical composition containing P13K inhibitor, and application of phosphoinositide kinase inhibitor and pharmaceutical composition | UNIV SUN YAT SEN | 2014-01-01 | — | — | CN | disclosed |
| US-8334292-B1 | Pyrimidine compounds and methods of making and using same | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2012-12-18 | — | — | US | disclosed |
| WO-2008124085-A2 | METHODS OF USING COMBINATIONS OF MEK AND JAK-2 INHIBITORS | EXELIXIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |