SCHEMBL2908091

SCHEMBL2908091

CC(C)(C)OC(=O)N1CC=C(c2ccc(N)cc2)CC1

nearest known ligand 0.60

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 1/20 0.60
PDK4 Q16654 1/20 0.56
NR1H2 P55055 1/20 0.54
GRM1 Q13255 10/20 0.53
GRM5 P41594 9/20 0.53
TNK2 Q07912 2/20 0.50
BTK Q06187 1/20 0.49
CYP11B2 P19099 1/20 0.49
CDK7 P50613 1/20 0.48
CDK13 Q14004 1/20 0.48
CDK12 Q9NYV4 1/20 0.48
HTR6 P50406 1/20 0.48
ATR Q13535 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29227506 1.00 NAMPT (0.60) NAMPTPDK4NR1H2GRM1GRM5
Carbamic Acid SCHEMBL31489255 0.96 NAMPT (0.57) NAMPTPDK4NR1H2GRM1GRM5
SCHEMBL25233965 0.92 NAMPT (0.53) NAMPTPDK4NR1H2GRM1GRM5
SCHEMBL8912847 0.89 NAMPT (0.63) NAMPTPDK4GRM1GRM5TNK2
SCHEMBL904049 0.88 NAMPT (0.61) NAMPTPDK4GRM1GRM5CYP11B2
SCHEMBL17002448 0.88 NR1H2 (0.52) NAMPTPDK4NR1H2GRM1GRM5
SCHEMBL30778341 0.87 NAMPT (0.56) NAMPTPDK4NR1H2GRM1GRM5
SCHEMBL15157008 0.87 NAMPT (0.56) NAMPTPDK4NR1H2GRM1GRM5
SCHEMBL29227507 0.87 NAMPT (0.49) NAMPTPDK4NR1H2GRM1GRM5
SCHEMBL31110456 0.87 NAMPT (0.58) NAMPTPDK4GRM1GRM5TNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072437-A1 HETEROARYL COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS ALPHINA THERAPEUTICS, INC. (US) 2025-04-03 WO disclosed
US-20250082762-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-03-13 US disclosed
US-20250073341-A1 BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-03-06 US disclosed
US-12161722-B2 Bifunctional heterocyclic compound having BTK degradation function via ubiquitin proteasome pathway, and use thereof KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2024-12-10 US disclosed
CN-118743770-A Positron Emission Tomography (PET) radiotracer for imaging macrophage colony stimulating factor 1 receptor (CSF 1R) in neuroinflammation 约翰霍普金斯大学 2024-10-08 CN disclosed
US-20240308994-A1 ISOXAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND USE THEREOF INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS (KR) 2024-09-19 US disclosed
US-20240285778-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2024-08-29 US disclosed
EP-4361153-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF Korea Research Institute of Chemical Technology (KR) 2024-05-01 EP disclosed
CN-113614087-B WEE1 inhibitor and preparation and application thereof 首药控股(北京)股份有限公司 2023-06-02 CN disclosed
WO-2023096304-A1 ISOXAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND USE THEREOF 한양대학교 에리카산학협력단 2023-06-01 WO disclosed
EP-1764360-A1 UREA DERIVATIVE Sankyo Company, Limited (JP) 2007-03-21 EP disclosed
EP-1764360-A1 UREA DERIVATIVE Sankyo Company, Limited (JP) 2007-03-21 EP disclosed
US-20070060577-A1 5-Oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA N.V. (BE) 2007-03-15 US disclosed
US-20070060577-A1 5-Oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA N.V. (BE) 2007-03-15 US disclosed
US-20070060577-A1 5-Oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase JANSSEN PHARMACEUTICA N.V. (BE) 2007-03-15 US disclosed
WO-2006138155-A1 SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR JANSSEN PHARMACEUTICA N.V. (BE) 2006-12-28 WO disclosed
US-20060281788-A1 SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR JANSSEN PHARMACEUTICA, N.V. (BE) 2006-12-14 US disclosed
US-20060189623-A1 Inhibitors of c-fms kinase ILLIG CARL R 2006-08-24 US disclosed
US-20060148812-A1 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-06 US disclosed
WO-2006047277-A2 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA, N.V. (BE) 2006-05-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060189623-A1 Inhibitors of c-fms kinase MUSK, TYK2, FES NAMPT 2502/4885PDK4 2546/4885NR1H2 3829/4885
US-20250073341-A1 BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF BTK, XIAP, SYK NAMPT 3067/4885PDK4 2458/4885NR1H2 4272/4885
US-20060281788-A1 SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR FLT3, MCL1, CSF1R NAMPT 665/4885PDK4 2317/4885NR1H2 271/4885
US-20250082762-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF BTK, XIAP, UBE3C NAMPT 3168/4885PDK4 2276/4885NR1H2 4249/4885
US-20060148812-A1 Inhibitors of c-fms kinase MUSK, TYK2, FES NAMPT 2502/4885PDK4 2546/4885NR1H2 3829/4885
US-12161722-B2 Bifunctional heterocyclic compound having BTK degradation function via ubiquitin proteasome pathway, and use thereof BTK, XIAP, SYK NAMPT 3067/4885PDK4 2458/4885NR1H2 4272/4885
US-20240285778-A1 NOVEL BIFUNCTIONAL HETEROCYCLIC COMPOUND HAVING BTK DEGRADATION FUNCTION VIA UBIQUITIN PROTEASOME PATHWAY, AND USE THEREOF BTK, XIAP, UBE3C NAMPT 3168/4885PDK4 2276/4885NR1H2 4249/4885
US-20070060577-A1 5-Oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase FLT3, FES, FGR NAMPT 2198/4885PDK4 1980/4885NR1H2 4232/4885
US-20240308994-A1 ISOXAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND USE THEREOF CSF1R, CSF3R, IL15RA NAMPT 2030/4885PDK4 963/4885NR1H2 700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.