Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 10/20 | 0.51 |
| ▸ | JAK2 | O60674 | 5/20 | 0.48 |
| ▸ | JAK1 | P23458 | 4/20 | 0.48 |
| ▸ | JAK3 | P52333 | 4/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29084261 | 0.83 | JAK2 (0.46) | TYK2JAK2JAK1NPC1RAB9A | |
| SCHEMBL28477215 | 0.81 | ILK (0.49) | TYK2JAK2JAK1JAK3SYK | |
| SCHEMBL29084256 | 0.81 | SYK (0.57) | TYK2JAK2JAK1JAK3RAB9A | |
| SCHEMBL28411950 | 0.78 | SYK (0.43) | TYK2JAK2JAK1SYK | |
| SCHEMBL29084264 | 0.78 | ALDH1A1 (0.46) | SYKALDH1A1 | |
| SCHEMBL29084257 | 0.77 | SYK (0.39) | TYK2JAK2SYKLMNA | |
| SCHEMBL30379305 | 0.76 | JAK2 (0.43) | TYK2JAK2JAK1JAK3NPC1 | |
| SCHEMBL28413940 | 0.76 | NNMT (0.43) | TYK2JAK2JAK1JAK3SYK | |
| SCHEMBL28890909 | 0.74 | SYK (0.44) | SYK | |
| SCHEMBL27171648 | 0.74 | NPC1 (0.46) | TYK2JAK2JAK1JAK3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936486-B | Heterocyclic compounds comprising pyridine as modulators of IL-12, IL-23 and/or IFN alpha responses | 百时美施贵宝公司 | 2023-09-22 | — | — | CN | disclosed |