Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.68 |
| ▸ | LTA4H | P09960 | 1/20 | 0.66 |
| ▸ | CRHBP | P24387 | 1/20 | 0.65 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25638621 | 0.92 | THRB (0.63) | ALDH1A1CYP3A4CYP2C9CYP2C19LTA4H | |
| SCHEMBL26102078 | 0.90 | CYP3A4 (0.58) | ALDH1A1CYP3A4CYP2C9CYP2C19LTA4H | |
| SCHEMBL6727553 | 0.85 | LTA4H (0.58) | ALDH1A1CYP3A4CYP2C9CYP2C19LTA4H | |
| SCHEMBL23873637 | 0.85 | ALDH1A1 (0.72) | ALDH1A1CYP3A4CYP2C9CYP2C19LTA4H | |
| SCHEMBL19198550 | 0.84 | RAB9A (0.69) | ALDH1A1CYP3A4CYP2C9CYP2C19LTA4H | |
| SCHEMBL19312422 | 0.84 | LTA4H (0.60) | ALDH1A1CYP3A4CYP2C9CYP2C19LTA4H | |
| SCHEMBL6833672 | 0.83 | LTA4H (0.73) | ALDH1A1CYP3A4CYP2C9CYP2C19LTA4H | |
| SCHEMBL1043015 | 0.83 | ALDH1A1 (0.73) | ALDH1A1CRHBPCRHR2GAACYP1A2 | |
| SCHEMBL171745 | 0.82 | ALDH1A1 (1.00) | ALDH1A1LTA4HGAACYP1A2CYP2D6 | |
| SCHEMBL13766317 | 0.81 | ALDH1A1 (0.73) | ALDH1A1CYP3A4CYP2C9CYP2C19LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-B1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARM CORP (US) | 2010-08-18 | — | — | EP | disclosed |
| US-20050222207-A1 | Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs | MEMORY PHARMACEUTICAL CORPORATION | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222207-A1 | Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs | PDE4A, PDE4B, PDE3B | ALDH1A1 300/4885CYP3A4 104/4885CYP2C9 468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.