Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30269658 | 0.77 | CA1 (0.47) | ALDH1A1HSD17B10TDP1PTGS2PTGS1 | |
| SCHEMBL28016001 | 0.77 | CA1 (0.47) | ALDH1A1HSD17B10TDP1PTGS2PTGS1 | |
| SCHEMBL119737 | 0.77 | CA1 (0.47) | ALDH1A1HSD17B10TDP1PTGS2PTGS1 | |
| SCHEMBL20003539 | 0.76 | ALDH1A1 (0.46) | ALDH1A1HSD17B10TDP1MEN1PABPC1 | |
| SCHEMBL65853 | 0.76 | FFAR4 (0.49) | ALDH1A1HSD17B10TDP1PTGS2PTGS1 | |
| SCHEMBL244098 | 0.76 | TRPV4 (0.52) | ALDH1A1HSD17B10TDP1SLC40A1CYP2C9 | |
| SCHEMBL29948975 | 0.76 | TRPV4 (0.52) | ALDH1A1HSD17B10TDP1SLC40A1CYP2C9 | |
| Ammonia Solution, Strong SCHEMBL26923048 | 0.74 | FFAR4 (0.47) | ALDH1A1HSD17B10TDP1PTGS2PTGS1 | |
| SCHEMBL31190599 | 0.73 | ALDH1A1 (0.40) | ALDH1A1HSD17B10TDP1SLC40A1MEN1 | |
| SCHEMBL307288 | 0.72 | ALDH1A1 (0.67) | ALDH1A1HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288414-A1 | SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME | Rappta Therapeutics Oy (FI) | 2023-12-13 | — | — | EP | disclosed |
| CN-116806217-A | Substituted cyclic modulators of protein phosphatase 2A (PP 2A) and methods of use thereof | 拉帕塔疗法公司 | 2023-09-26 | — | — | CN | disclosed |
| WO-2022167867-A1 | SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME | RAPPTA THERAPEUTICS OY (FI) | 2022-08-11 | — | — | WO | disclosed |