Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.52 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL244098 | 1.00 | TRPV4 (0.52) | TRPV4SLC40A1ALDH1A1HSD17B10TDP1 | |
| SCHEMBL31190599 | 0.84 | ALDH1A1 (0.40) | TRPV4SLC40A1ALDH1A1HSD17B10TDP1 | |
| SCHEMBL3701877 | 0.79 | KDM4E (0.57) | TRPV4SLC40A1ALDH1A1CYP2C9SLC22A6 | |
| SCHEMBL30845950 | 0.79 | TRPV4 (0.52) | TRPV4SLC40A1TDP1CYP2C9SLC22A6 | |
| SCHEMBL5077871 | 0.79 | TRPV4 (0.52) | TRPV4SLC40A1ALDH1A1CYP2C9SLC22A6 | |
| SCHEMBL18231250 | 0.79 | KCNH2 (0.55) | TRPV4SLC40A1CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL2169084 | 0.79 | TRPV4 (0.52) | TRPV4SLC40A1TDP1CYP2C9SLC22A6 | |
| SCHEMBL5077872 | 0.78 | KDM4E (0.55) | TRPV4SLC40A1ALDH1A1CYP2C9SLC22A6 | |
| Hydrochloric Acid SCHEMBL29970288 | 0.78 | TRPV4 (0.50) | TRPV4SLC40A1TDP1CYP2C9SLC22A6 | |
| Hydrochloric Acid SCHEMBL27930121 | 0.78 | KDM4E (0.55) | TRPV4SLC40A1ALDH1A1CYP2C9SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4482587-A1 | EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF | Biogen MA Inc. (US) | 2025-01-01 | — | — | EP | disclosed |
| CN-119118894-A | TRPV4 receptor ligands | 犹他大学研究基金会 | 2024-12-13 | — | — | CN | disclosed |
| CN-118984824-A | Cannabinoid receptor compounds and uses thereof | 长春金赛药业有限责任公司 | 2024-11-19 | — | — | CN | disclosed |
| WO-2023164063-A1 | EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF | BIOGEN MA INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| CN-109952289-B | TRPV4 antagonists | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2022-12-09 | — | — | CN | disclosed |
| EP-4061124-A1 | TRPV4 RECEPTOR LIGANDS | University of Utah Research Foundation (US) | 2022-09-28 | — | — | EP | disclosed |
| CN-115052478-A | TRPV4 receptor ligands | 犹他大学研究基金会 | 2022-09-13 | — | — | CN | disclosed |