Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.68 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.68 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.68 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.68 |
| ▸ | CETP | P11597 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30806792 | 1.00 | PDK1 (0.68) | PDK1PDK2PDK3PDK4CETP | |
| SCHEMBL19280535 | 0.89 | PDK1 (0.68) | PDK1PDK2PDK3PDK4CETP | |
| SCHEMBL5706504 | 0.86 | CETP (0.71) | PDK1PDK2PDK3PDK4CETP | |
| SCHEMBL14571971 | 0.84 | PDK1 (0.62) | PDK1PDK2PDK3PDK4HTT | |
| SCHEMBL2087952 | 0.82 | CETP (0.67) | PDK1PDK2PDK3PDK4CETP | |
| SCHEMBL6347970 | 0.81 | PDK1 (1.00) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL30641363 | 0.81 | PDK1 (0.68) | PDK1PDK2PDK3PDK4HTT | |
| SCHEMBL1179607 | 0.81 | PDK1 (0.68) | PDK1PDK2PDK3PDK4HTT | |
| SCHEMBL2301094 | 0.78 | CETP (0.68) | PDK1PDK2PDK3PDK4CETP | |
| SCHEMBL8243174 | 0.78 | CETP (0.62) | CETPHTTLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561561-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | Septerna, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024026076-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | SEPTERNA, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| WO-2024026076-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | SEPTERNA, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| US-20230293535-A1 | ERBB/BTK INHIBITORS | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2023-09-21 | — | — | US | disclosed |
| WO-2019149164-A1 | ERBB/BTK INHIBITORS | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2019-08-08 | — | — | WO | disclosed |
| US-8217172-B2 | Solid forms of 1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-10 | — | — | US | disclosed |
| US-8217172-B2 | Solid forms of 1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-10 | — | — | US | disclosed |
| US-8217172-B2 | Solid forms of 1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-07-10 | — | — | US | disclosed |
| CN-101925597-A | Solid forms of 1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1h-benzo[d]imidazol-2-yl)urea | VERTEX PHARMA | 2010-12-22 | — | — | CN | disclosed |
| CN-101903376-A | Process and intermediates for the production of aminobenzimidazole ureas | VERTEX PHARMA | 2010-12-01 | — | — | CN | disclosed |
| US-20090163715-A1 | Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| US-20090163715-A1 | Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-25 | — | — | US | disclosed |
| WO-2009076200-A2 | SOLID FORMS OF 1-ETHYL-3-(5-(5-FLUOROPYRIDIN-3-YL)-7-(PYRIMIDIN-2-YL)-1H-BENZO[D]IMIDAZOL-2-YL)UREA | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-06-18 | — | — | WO | disclosed |
| US-20090149651-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-06-11 | — | — | US | disclosed |
| WO-2009061875-A2 | PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-05-14 | — | — | WO | disclosed |
| WO-2009061875-A2 | PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-05-14 | — | — | WO | disclosed |
| EP-1889827-A1 | INTERMEDIATE IN PRODUCTION OF [2-(3,3,5,5-TETRAMETHYLCYCLOHEXYL)PHENYL]PIPERAZINE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2008-02-20 | — | — | EP | disclosed |
| EP-0619804-B1 | HERBICIDAL ACYLATED AMINO-(PHENYL- OR PYRIDINYL- OR THIENYL-)-PHENYL DERIVATIVES | DU PONT (US) | 1996-05-22 | — | — | EP | disclosed |
| EP-0619804-A1 | HERBICIDAL ACYLATED AMINO-(PHENYL- OR PYRIDINYL- OR THIENYL-)-PHENYL DERIVATIVES. | DU PONT (US) | 1994-10-19 | — | — | EP | disclosed |
| WO-1993011097-A1 | HERBICIDAL ACYLATED AMINO-(PHENYL- OR PYRIDINYL- OR THIENYL-)-PHENYL DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163715-A1 | Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound | ICAM1, HRH1, HRH2 | PDK1 1233/4885PDK2 1441/4885PDK3 2372/4885 |
| US-20090149651-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS | TOP2B, TOP1, TOP2A | PDK1 2442/4885PDK2 1408/4885PDK3 1648/4885 |
| US-20230293535-A1 | ERBB/BTK INHIBITORS | ERBB2, BTK, ERBB3 | PDK1 1269/4885PDK2 2659/4885PDK3 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.