Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | PTPRC | P08575 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 1/20 | 0.53 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5706504 | 0.91 | CETP (0.71) | CETPL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL16767087 | 0.88 | CETP (0.59) | CETPL3MBTL1LCKCTSLPTPRC | |
| SCHEMBL14447514 | 0.88 | TACR1 (0.64) | CETPMAPTKDM4EMEN1KMT2A | |
| SCHEMBL8243174 | 0.88 | CETP (0.62) | CETPL3MBTL1MAPTTP53KDM4E | |
| SCHEMBL1358972 | 0.84 | CETP (0.54) | CETPL3MBTL1LCKCTSLPTPRC | |
| SCHEMBL397003 | 0.83 | PDK1 (0.67) | CETPL3MBTL1KDM4EALOX12LMNA | |
| SCHEMBL2301094 | 0.83 | CETP (0.68) | CETPL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL2556303 | 0.82 | CETP (0.49) | CETPL3MBTL1LCKCTSLPTPRC | |
| SCHEMBL2909082 | 0.82 | PDK1 (0.68) | CETPL3MBTL1MAPTKDM4EMEN1 | |
| SCHEMBL1524281 | 0.82 | CETP (0.61) | CETPL3MBTL1MAPTTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163900-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163900-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163900-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100228024-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-09 | — | — | US | disclosed |
| US-20100228024-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-09 | — | — | US | disclosed |
| US-20100228024-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-09-09 | — | — | US | disclosed |
| US-7750149-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750149-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750149-B2 | Seven-membered heterocyclic carbenes and their metal complexes | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-07-06 | — | — | US | disclosed |
| EP-1879872-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006110198-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229448-A1 | Seven-membered heterocyclic carbenes and their metal complexes | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100228024-A1 | SEVEN-MEMBERED HETEROCYCLIC CARBENES AND THEIR METAL COMPLEXES | CYCS, COG7, SOD1 | CETP 4280/4885L3MBTL1 4409/4885LCK 1479/4885 |
| US-20060229448-A1 | Seven-membered heterocyclic carbenes and their metal complexes | CYCS, COG7, SOD1 | CETP 4280/4885L3MBTL1 4409/4885LCK 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.