Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | EEF2K | O00418 | 2/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.31 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | EEF2 | P13639 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18584635 | 0.71 | BRD4 (0.49) | BRD4CNR2BRD9MAPK1PARP1 | |
| Hydrochloric Acid SCHEMBL18584529 | 0.69 | BRD4 (0.47) | BRD4CNR2BRD9MAPK1PARP1 | |
| SCHEMBL30647145 | 0.66 | BRD4 (0.35) | BRD4CNR2BRD9MAPK1PARP1 | |
| SCHEMBL29092183 | 0.66 | BRD4 (0.35) | BRD4CNR2BRD9MAPK1PARP1 | |
| SCHEMBL30647220 | 0.66 | BRD4 (0.35) | BRD4CNR2BRD9MAPK1PARP1 | |
| SCHEMBL28861326 | 0.64 | BRD4 (0.44) | BRD4CNR2EEF2KBRD9MAPK1 | |
| SCHEMBL28581846 | 0.63 | BRD4 (0.41) | BRD4CNR2PARP1TSHRMKNK2 | |
| SCHEMBL28227744 | 0.62 | BRD4 (0.43) | BRD4CNR2BRD9OPRM1NPC1 | |
| SCHEMBL29092189 | 0.62 | BRD4 (0.43) | BRD4CNR2BRD9MAPK1 | |
| SCHEMBL27543552 | 0.57 | PARP1 (0.45) | BRD4PARP1PARP15PARP10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137542-B | Pyridone dicarboxamides as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2023-10-27 | — | — | CN | disclosed |