Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 5/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.34 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13140089 | 0.94 | RARB (0.40) | ALDH1A1HTTSMN1; SMN2HPGDPTGDR2 | |
| SCHEMBL13117586 | 0.90 | FFAR1 (0.38) | ALDH1A1HTTSMN1; SMN2HPGDPTGDR2 | |
| SCHEMBL13117587 | 0.86 | ALDH1A1 (0.49) | ALDH1A1HTTSMN1; SMN2HPGDPTGDR2 | |
| SCHEMBL2913113 | 0.85 | TSHR (0.48) | ALDH1A1HTTSMN1; SMN2HPGDPTGDR2 | |
| SCHEMBL2913115 | 0.85 | ALDH1A1 (0.40) | ALDH1A1HTTSMN1; SMN2HPGDPTGDR2 | |
| SCHEMBL13139898 | 0.84 | ALDH1A1 (0.42) | ALDH1A1HTTSMN1; SMN2HPGDPTGDR2 | |
| SCHEMBL13117550 | 0.80 | CD274 (0.51) | CD274PDCD1 | |
| SCHEMBL2906794 | 0.78 | GAA (0.39) | ALDH1A1HTTSMN1; SMN2HPGDCD274 | |
| SCHEMBL13117560 | 0.77 | ALDH1A1 (0.36) | ALDH1A1HTTSMN1; SMN2HPGDPTGDR2 | |
| SCHEMBL13117607 | 0.77 | SMN1; SMN2 (0.37) | ALDH1A1HTTSMN1; SMN2HPGDPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267775-A1 | OXADIAZOLIDINEDIONE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-10-21 | — | — | US | disclosed |
| EP-2216330-A1 | OXADIAZOLIDINEDIONE COMPOUND | Astellas Pharma Inc. (JP) | 2010-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267775-A1 | OXADIAZOLIDINEDIONE COMPOUND | GPR119, GLP1R, GPR4 | ALDH1A1 2370/4885HTT 2299/4885SMN1; SMN2 3468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.