Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27854183 | 0.85 | LMNA (0.42) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27791901 | 0.83 | GSK3A (0.37) | ALDH1A1KMT2ASMN1; SMN2LMNAPKM | |
| Bromide SCHEMBL28311088 | 0.81 | ALDH1A1 (0.42) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5969762 | 0.80 | ADRA1D (0.38) | ALDH1A1KMT2AGAA | |
| SCHEMBL16385837 | 0.79 | ALDH1A1 (0.43) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27920548 | 0.78 | SMN1; SMN2 (0.34) | THRBALDH1A1SMN1; SMN2LMNATDP1 | |
| SCHEMBL27836159 | 0.77 | LMNA (0.36) | KMT2ASMN1; SMN2LMNA | |
| SCHEMBL10619250 | 0.77 | SIGMAR1 (0.36) | ALDH1A1MEN1KMT2ACYP1A2GAA | |
| Iodide SCHEMBL28054984 | 0.77 | SMN1; SMN2 (0.33) | THRBALDH1A1SMN1; SMN2LMNATDP1 | |
| Bromide SCHEMBL29099281 | 0.76 | SIGMAR1 (0.41) | MAPTALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116803980-A | Preparation method of tetrahydropyridine derivative and hexahydropyridine derivative | 中国科学院化学研究所 | 2023-09-26 | — | — | CN | disclosed |