Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Dihydroxyacetone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydroxyacetone SCHEMBL20798012 | 0.96 | KDM4E (0.35) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Dihydroxyacetone SCHEMBL43279 | 0.96 | KDM4E (0.35) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Dihydroxyacetone SCHEMBL290385 | 0.84 | — | — | |
| Pyrophosphoric Acid SCHEMBL10768840 | 0.82 | FDPS (0.56) | BLMTDP1 | |
| Dihydroxyacetone SCHEMBL70 | 0.80 | — | — | |
| Dihydroxyacetone SCHEMBL2555249 | 0.80 | OR51E2 (0.40) | TDP1OR51E2 | |
| Glycolic Acid SCHEMBL5586777 | 0.79 | TSHR (0.47) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| Phosphoric Acid SCHEMBL6516958 | 0.78 | GABRR1 (0.38) | KDM4ELMNABLMOR51E2 | |
| Phosphoric Acid SCHEMBL28253210 | 0.78 | TDP1 (0.50) | MMP2MEN1LMNAHPGDTSHR | |
| Glycolic Acid SCHEMBL27262386 | 0.76 | TSHR (0.45) | KDM4EMMP2THRBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427222-B1 | HYGIENE ARTICLE HAVING CALCIUM SUGAR PHOSPHATE | PROCTER & GAMBLE (US) | 2013-06-19 | — | — | EP | claimed |
| EP-2427222-A2 | HYGIENE ARTICLE HAVING CALCIUM SUGAR PHOSPHATE | The Procter & Gamble Company (US) | 2012-03-14 | — | — | EP | claimed |
| WO-2010129444-A2 | HYGIENE ARTICLE HAVING CALCIUM SUGAR PHOSPHATE | THE PROCTER & GAMBLE COMPANY (US) | 2010-11-11 | — | — | WO | claimed |
| US-20100285096-A1 | Hygiene Article Having Calcium Sugar Phosphate | PROCTER & GAMBLE COMPANY, THE | 2010-11-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100285096-A1 | Hygiene Article Having Calcium Sugar Phosphate | PSPH, PPM1G, G6PC1 | KDM4E 3433/4885MMP2 1834/4885THRB 1504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.