Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11347398 | 0.82 | ALDH1A1 (0.43) | BRD4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL1530140 | 0.80 | SLC6A2 (0.41) | BRD4SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL23547262 | 0.79 | CYP17A1 (0.56) | SLC6A4SLC6A2SLC6A3KCNH2HPGD | |
| SCHEMBL8864731 | 0.73 | HPGD (0.51) | SLC6A4SLC6A2SLC6A3KCNH2HPGD | |
| SCHEMBL473085 | 0.73 | L3MBTL1 (0.50) | HPGDSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL29669768 | 0.73 | L3MBTL1 (0.50) | HPGDSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL27808004 | 0.73 | MAPK1 (0.55) | BRD4SMN1; SMN2ALDH1A1MAPK1KMT2A | |
| SCHEMBL12678751 | 0.73 | SLC6A4 (0.53) | SLC6A4SLC6A2SLC6A3KCNH2HPGD | |
| SCHEMBL11233535 | 0.73 | PTGS1 (0.55) | POLBHPGDCYP17A1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5324234 | 0.72 | KDM4E (0.59) | POLBHPGDRECQLSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |