Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TRPC5 | Q9UL62 | 4/20 | 0.59 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.54 |
| ▸ | TNF | P01375 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16027799 | 0.91 | TSHR (0.62) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL16028784 | 0.87 | TRPC5 (0.64) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL16028393 | 0.87 | TRPC5 (0.66) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL18834872 | 0.86 | TRPC5 (0.65) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL16068298 | 0.85 | TRPC5 (0.60) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL16028537 | 0.85 | TRPC5 (0.63) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL16363971 | 0.84 | ALDH1A1 (0.54) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL16076222 | 0.84 | TRPC5 (0.60) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL19375261 | 0.82 | TSHR (0.66) | TSHRPOLBTRPC5TRPC4KCNH2 | |
| SCHEMBL16028290 | 0.82 | TRPC5 (0.60) | TSHRPOLBTRPC5TRPC4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115636831-A | Fused pyrimidinediones, their use and pharmaceutical compositions | 中国药科大学 | 2023-01-24 | — | — | CN | disclosed |