Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.30 |
| ▸ | TUBB | P07437 | 1/20 | 0.30 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.30 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.30 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916163 | 0.87 | CRBN (0.38) | CRBNCYP3A4ADRB1NR3C2 | |
| SCHEMBL2915218 | 0.86 | CYP3A4 (0.40) | CRBNCYP3A4ADRB1WDR5EPHX2 | |
| SCHEMBL2910562 | 0.85 | HPGD (0.41) | CRBNCYP3A4ADRB1RAB9ANPC1 | |
| SCHEMBL1530654 | 0.82 | AURKB (0.39) | CRBNCYP3A4ADRB1GPR119WDR5 | |
| SCHEMBL2909904 | 0.82 | CYP3A4 (0.40) | CRBNCYP3A4ADRB1WDR5 | |
| SCHEMBL2910585 | 0.82 | CYP3A4 (0.40) | CRBNCYP3A4ADRB1WDR5 | |
| SCHEMBL2915217 | 0.82 | CYP3A4 (0.42) | CRBNCYP3A4ADRB1L3MBTL1NPC1 | |
| SCHEMBL2910588 | 0.82 | CYP3A4 (0.40) | CRBNCYP3A4ADRB1WDR5 | |
| SCHEMBL2914330 | 0.82 | CYP3A4 (0.40) | CRBNCYP3A4ADRB1WDR5 | |
| SCHEMBL2906898 | 0.82 | CYP3A4 (0.40) | CRBNCYP3A4ADRB1WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |