Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910804 | 0.79 | ALDH1A1 (0.43) | MAPTALDH1A1LMNASMN1; SMN2PKM | |
| SCHEMBL2915008 | 0.75 | SIGMAR1 (0.42) | MAPTMAPK1TDP1 | |
| SCHEMBL2061689 | 0.72 | SIGMAR1 (0.42) | MAPTALDH1A1LMNAPKMMAPK1 | |
| SCHEMBL2062474 | 0.72 | SIGMAR1 (0.42) | MAPTALDH1A1LMNAPKMMAPK1 | |
| SCHEMBL3435490 | 0.70 | CTSB (0.52) | CYP1A2MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2061632 | 0.70 | ALK (0.42) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL2908344 | 0.69 | GAA (0.38) | MAPTSMN1; SMN2GAA | |
| SCHEMBL16571285 | 0.68 | MEN1 (0.42) | ALDH1A1LMNASMN1; SMN2KMT2AGAA | |
| SCHEMBL2061311 | 0.67 | ALK (0.42) | CYP1A2CYP2C19MAPTALDH1A1LMNA | |
| SCHEMBL2482410 | 0.65 | ALDH1A1 (0.36) | MAPTALDH1A1LMNASMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |