Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911027 | 0.75 | CASP6 (0.38) | MAPTMAPK1TDP1 | |
| SCHEMBL2061402 | 0.73 | SIGMAR1 (0.52) | SIGMAR1ABCB1 | |
| SCHEMBL2062474 | 0.72 | SIGMAR1 (0.42) | SIGMAR1MAPTMAPK1 | |
| SCHEMBL2061689 | 0.72 | SIGMAR1 (0.42) | SIGMAR1MAPTMAPK1 | |
| SCHEMBL2917832 | 0.71 | SIGMAR1 (0.55) | SIGMAR1ABCB1 | |
| SCHEMBL10608404 | 0.70 | SIGMAR1 (0.71) | SIGMAR1ABCB1 | |
| SCHEMBL2062784 | 0.68 | HTT (0.41) | MAPTMAPK1 | |
| SCHEMBL20061133 | 0.67 | HTT (0.43) | MAPTMAPK1S1PR1 | |
| SCHEMBL2916757 | 0.67 | MTNR1B (0.43) | SIGMAR1 | |
| SCHEMBL24003783 | 0.66 | EHMT2 (0.37) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684874-B1 | Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors | CEPHALON INC (US) | 2017-05-17 | — | — | EP | disclosed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |