Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905929 | 0.91 | CSF1R (0.53) | CSF1RKCNH2SCN5ABRD4EPHA2 | |
| SCHEMBL2912641 | 0.90 | CSF1R (0.60) | CSF1RKCNH2SCN5ABRD4EPHA2 | |
| SCHEMBL2907522 | 0.90 | CSF1R (0.48) | CSF1RKCNH2SCN5AMAPTERBB2 | |
| SCHEMBL2911700 | 0.90 | KCNH2 (0.51) | CSF1RKCNH2SCN5AMAPTEGFR | |
| SCHEMBL2908706 | 0.89 | KCNH2 (0.46) | CSF1RKCNH2SCN5AMEN1MAPT | |
| SCHEMBL2912772 | 0.83 | MAPT (0.46) | CSF1RKCNH2SCN5AMAPTEPHA2 | |
| SCHEMBL2911555 | 0.82 | KCNH2 (0.53) | CSF1RKCNH2SCN5AMAPT | |
| SCHEMBL2904662 | 0.80 | CSF1R (0.84) | CSF1RKCNH2SCN5A | |
| SCHEMBL2911202 | 0.80 | CSF1R (0.70) | CSF1RKCNH2SCN5AMEN1MAPT | |
| SCHEMBL2909682 | 0.79 | CSF1R (0.64) | CSF1RKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |