Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 6/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.47 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.47 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774515 | 0.98 | NPC1 (0.51) | NPC1ALDH1A1MEN1KMT2AFABP4 | |
| SCHEMBL11361974 | 0.85 | ALDH1A1 (0.65) | ALDH1A1MEN1KMT2AFABP4APOBEC3A | |
| SCHEMBL4502911 | 0.84 | HRH3 (0.57) | NPC1ALDH1A1MEN1KMT2AFABP4 | |
| SCHEMBL4878350 | 0.84 | HDAC3 (0.55) | ALDH1A1KMT2APARP1PARP2PARP3 | |
| SCHEMBL2228234 | 0.84 | KDM4E (0.58) | NPC1ALDH1A1MEN1KMT2APARP1 | |
| SCHEMBL6842740 | 0.84 | LMNA (0.54) | ALDH1A1PARP1PARP2KDM4E | |
| SCHEMBL885730 | 0.84 | CYP2A13 (0.55) | ALDH1A1PARP1PARP2KDM4E | |
| SCHEMBL11871949 | 0.83 | MEN1 (0.56) | ALDH1A1MEN1KMT2AAPOBEC3AAPOBEC3G | |
| SCHEMBL7433040 | 0.83 | ALDH1A1 (0.67) | ALDH1A1MEN1KMT2AFABP4APOBEC3A | |
| Hydrochloric Acid SCHEMBL27770346 | 0.83 | HRH3 (0.55) | NPC1ALDH1A1KMT2AFABP4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11203582-B2 | Benzamide derivatives for inhibiting endoplasmic reticulum (ER) stress | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2021-12-21 | — | — | US | disclosed |
| US-20200199094-A1 | BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2020-06-25 | — | — | US | disclosed |
| WO-2018232264-A1 | BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2018-12-20 | — | — | WO | disclosed |
| EP-2784065-B1 | GLYCINE REUPTAKE INHIBITOR AND USE THEREOF | BEIJING MEDISAN TECHNOLOGY CO LTD (CN) | 2016-10-05 | — | — | EP | disclosed |
| EP-1940786-B1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LTD (GB) | 2010-08-18 | — | — | EP | disclosed |
| US-20080255105-A1 | Biphenyl Derivatives and Their Use in Treating Hepatitis C | ARROW THERAPEUTICS LIMITED (GB) | 2008-10-16 | — | — | US | disclosed |
| EP-1940786-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | Arrow Therapeutics Limited (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007031791-A1 | BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255105-A1 | Biphenyl Derivatives and Their Use in Treating Hepatitis C | NR4A1, NR0B1, NR1H4 | NPC1 146/4885ALDH1A1 441/4885MEN1 3163/4885 |
| US-20200199094-A1 | BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | HSPA5, TMBIM6, BAD | NPC1 2297/4885ALDH1A1 3506/4885MEN1 4714/4885 |
| US-11203582-B2 | Benzamide derivatives for inhibiting endoplasmic reticulum (ER) stress | HSPA5, TMBIM6, BAD | NPC1 2297/4885ALDH1A1 3506/4885MEN1 4714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.