Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29123428 | 0.91 | LTA4H (0.40) | SCN9ALTA4HP2RX3PPARDPPARA | |
| SCHEMBL29123660 | 0.88 | SCN9A (0.37) | SCN9AS1PR1LTA4HP2RX3MAPT | |
| SCHEMBL30731757 | 0.83 | MAPT (0.38) | IDH1SCN9ASCN10AS1PR1LTA4H | |
| SCHEMBL29123787 | 0.83 | MAPT (0.38) | IDH1SCN9ASCN10AS1PR1LTA4H | |
| SCHEMBL29123726 | 0.80 | LTA4H (0.42) | IDH1SCN9ASCN10ALTA4HMAPT | |
| SCHEMBL29123730 | 0.80 | LTA4H (0.42) | IDH1SCN9ASCN10ALTA4HMAPT | |
| SCHEMBL29123581 | 0.80 | SCN9A (0.44) | SCN9ALTA4HMAPTPPARDPPARA | |
| SCHEMBL30731593 | 0.78 | IDH1 (0.41) | IDH1SCN9ASCN10AS1PR1HCRTR1 | |
| SCHEMBL24665376 | 0.75 | LTA4H (0.56) | SCN9ASCN10ALTA4HMAPT | |
| SCHEMBL29123411 | 0.75 | LTA4H (0.56) | SCN9ASCN10ALTA4HMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117015537-A | Heteroaryl aminopropanol derivatives as inhibitors of LTA4H | 诺华股份有限公司 | 2023-11-07 | — | — | CN | disclosed |