Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.32 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913880 | 0.83 | CYP3A4 (0.56) | CYP3A4TRPV1 | |
| SCHEMBL2913728 | 0.83 | CYP3A4 (0.56) | CYP3A4TRPV1 | |
| SCHEMBL2908324 | 0.83 | TRPV1 (0.39) | CYP3A4TRPV1EPHX2NR1H4 | |
| SCHEMBL2910649 | 0.83 | TDP2 (0.33) | TRPV1NR3C2EPHX2NR1H4 | |
| SCHEMBL2111740 | 0.82 | CYP3A4 (0.39) | CYP3A4TRPV1NR3C2HDAC1EPHX2 | |
| SCHEMBL2111743 | 0.82 | CYP3A4 (0.39) | CYP3A4TRPV1NR3C2HDAC1EPHX2 | |
| SCHEMBL2909890 | 0.81 | CA1 (0.42) | TRPV1EPHX2NR1H4 | |
| SCHEMBL2912524 | 0.81 | RAB9A (0.44) | TRPV1EPHX2NR1H4 | |
| SCHEMBL2111741 | 0.80 | CYP3A4 (0.39) | CYP3A4TRPV1NR3C2HDAC1EPHX2 | |
| SCHEMBL1530141 | 0.78 | TRPV1 (0.42) | CYP3A4TRPV1NR3C2HDAC1PIP4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-2203430-A1 | N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS | Abbott Laboratories (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009039135-A1 | N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |