Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912906 | 0.83 | CYP3A4 (0.39) | TRPV1CYP3A4EPHX2NR1H4 | |
| SCHEMBL2910649 | 0.82 | TDP2 (0.33) | TRPV1EPHX2NR1H4ALDH1A1 | |
| SCHEMBL2113416 | 0.81 | CYP3A4 (0.56) | CYP3A4GRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL2909890 | 0.80 | CA1 (0.42) | TRPV1EPHX2NR1H4KDM4EALDH1A1 | |
| SCHEMBL2912524 | 0.80 | RAB9A (0.44) | TRPV1EPHX2NR1H4KDM4EALDH1A1 | |
| SCHEMBL1530884 | 0.78 | DDB1 (0.39) | TRPV1CYP3A4EPHX2NR1H4GRIN1 | |
| SCHEMBL2908431 | 0.76 | KAT2B (0.32) | ALDH1A1 | |
| SCHEMBL2915590 | 0.75 | GAA (0.36) | EPHX2NR1H4HPGD | |
| SCHEMBL2916119 | 0.73 | ALOX12 (0.37) | TRPV1CYP3A4EPHX2NR1H4 | |
| SCHEMBL2914859 | 0.73 | CYP3A4 (0.40) | CYP3A4EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2725015-A1 | Uracil or thymine derivative for treating hepatitis c | AbbVie Bahamas Ltd. (BS) | 2014-04-30 | — | — | EP | claimed |
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |