Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910392 | 1.00 | ALDH1A1 (0.35) | ALDH1A1L3MBTL1KMT2AGRM2MEN1 | |
| SCHEMBL2909834 | 0.89 | ALDH1A1 (0.33) | ALDH1A1L3MBTL1KMT2AGRM2LMNA | |
| SCHEMBL2910867 | 0.89 | ALDH1A1 (0.33) | ALDH1A1L3MBTL1KMT2AGRM2LMNA | |
| SCHEMBL2903975 | 0.88 | POLB (0.39) | ALDH1A1L3MBTL1KMT2AMEN1POLB | |
| SCHEMBL2913211 | 0.88 | POLB (0.46) | ALDH1A1L3MBTL1KMT2AMEN1POLB | |
| SCHEMBL2907498 | 0.88 | RAB9A (0.38) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| SCHEMBL2904441 | 0.88 | ALDH1A1 (0.35) | ALDH1A1L3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL2904881 | 0.87 | RAB9A (0.39) | ALDH1A1KMT2AMEN1LMNAMAPK1 | |
| SCHEMBL2911760 | 0.86 | GSK3B (0.45) | ALDH1A1L3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL2909820 | 0.86 | GSK3B (0.45) | ALDH1A1L3MBTL1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |