Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28238225 | 0.80 | KMO (0.43) | MAP4K4KMOAAK1POLBKDM4E | |
| SCHEMBL28669409 | 0.78 | MAP4K4 (0.48) | MAP4K4KMOMEN1KMT2AMAPT | |
| SCHEMBL29623827 | 0.78 | MAP4K4 (0.48) | MAP4K4KMOMEN1KMT2AMAPT | |
| SCHEMBL15577810 | 0.78 | DYRK1A (0.46) | KMOMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL29131086 | 0.77 | BTK (0.39) | MEN1KMT2AL3MBTL1POLBKDM4E | |
| SCHEMBL3401316 | 0.76 | ROCK2 (0.58) | MAPTRAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL28609201 | 0.76 | AOC3 (0.36) | MAP4K4MAPTRAB9ANPC1POLB | |
| SCHEMBL25854880 | 0.76 | MAPT (0.45) | KMOMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL978578 | 0.76 | MEN1 (0.44) | MAP4K4KMOMEN1KMT2AMAPT | |
| SCHEMBL12921675 | 0.76 | ADRB2 (0.47) | MAP4K4KMOMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117088851-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-11-21 | — | — | CN | disclosed |