SCHEMBL29133365

SCHEMBL29133365

CCOC(=O)CC(=O)CC(O)CC#N

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.45
MGAM O43451 1/20 0.45
SI P14410 1/20 0.45
MGAM2 Q2M2H8 1/20 0.45
KDM4E B2RXH2 7/20 0.36
HTT P42858 1/20 0.36
HPGD P15428 4/20 0.35
TDP1 Q9NUW8 2/20 0.35
ALDH1A1 P00352 7/20 0.34
TRPA1 O75762 1/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 5/20 0.33
MAPT P10636 4/20 0.33
HSD17B10 Q99714 3/20 0.33
ALOX12 P18054 2/20 0.33
ALOX15 P16050 1/20 0.33
PKM P14618 1/20 0.33
CASP1 P29466 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL395418 0.86 MGAM (0.41) GAAMGAMSIMGAM2KDM4E
SCHEMBL391523 0.86 MGAM (0.41) GAAMGAMSIMGAM2KDM4E
SCHEMBL198108 0.86 MGAM (0.41) GAAMGAMSIMGAM2KDM4E
SCHEMBL15483303 0.84 FAAH (0.45) KDM4EHPGDALDH1A1TSHRSMN1; SMN2
SCHEMBL4264982 0.84 FAAH (0.45) KDM4EHPGDALDH1A1TSHRSMN1; SMN2
SCHEMBL29133366 0.84 MGAM (0.35) GAAMGAMSIMGAM2HTT
SCHEMBL8155691 0.84 TSHR (0.33) KDM4ETDP1ALDH1A1TSHRMAPT
SCHEMBL29133363 0.80 ALDH1A1 (0.39) GAAKDM4EHPGDALDH1A1MEN1
Ethyl Acetate SCHEMBL27915037 0.80 ALDH1A1 (0.47) GAAMGAMSIMGAM2KDM4E
SCHEMBL583479 0.79 CTSS (0.39) HDAC3HDAC1HDAC2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117326977-A Preparation method of 6-cyano-5-hydroxy-3-oxo caproate 浙江财和生物科技有限公司 2024-01-02 CN disclosed