Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912974 | 0.88 | GSK3B (0.47) | GSK3BKMT2AMEN1MAPTRAB9A | |
| SCHEMBL2909829 | 0.86 | HCRTR1 (0.41) | CNR1CNR2 | |
| SCHEMBL1219461 | 0.85 | GSK3B (0.49) | GSK3BKMT2AMAPTALDH1A1LMNA | |
| SCHEMBL2908173 | 0.85 | GSK3B (0.47) | GSK3BDPP4CNR1CNR2 | |
| SCHEMBL2910724 | 0.83 | GSK3B (0.42) | GSK3BKMT2AMEN1MAPTRAB9A | |
| SCHEMBL2909927 | 0.83 | GSK3B (0.49) | GSK3BKMT2AMAPTALDH1A1MAPK1 | |
| SCHEMBL2913237 | 0.83 | GSK3B (0.42) | GSK3BKMT2AMEN1MAPTRAB9A | |
| SCHEMBL2912944 | 0.83 | GSK3B (0.42) | GSK3BKMT2AMEN1MAPTRAB9A | |
| SCHEMBL2909845 | 0.83 | GSK3B (0.42) | GSK3BKMT2AMEN1MAPTRAB9A | |
| SCHEMBL2909838 | 0.80 | GSK3B (0.47) | GSK3BKMT2AMEN1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |