Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SSTR4 | P31391 | 10/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SSTR1 | P30872 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28738249 | 0.92 | PKM (0.45) | KDM4EALDH1A1MAPTSSTR4KMT2A | |
| SCHEMBL18989937 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1MAPTKMT2AELANE | |
| SCHEMBL30689342 | 0.80 | HCRTR1 (0.46) | KDM4EALDH1A1SSTR4SSTR1HCRTR1 | |
| SCHEMBL1597855 | 0.79 | NOS3 (0.42) | KDM4EALDH1A1MAPTSSTR4CYP2C19 | |
| SCHEMBL982469 | 0.78 | NPC1 (0.42) | KDM4EMAPTSSTR4CYP2C19KMT2A | |
| SCHEMBL4945110 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1SSTR4CYP2C19KMT2A | |
| SCHEMBL29094492 | 0.77 | MAPT (0.41) | KDM4EALDH1A1MAPTSSTR4CYP2C19 | |
| SCHEMBL28683997 | 0.76 | PLAU (0.44) | KDM4EMAPTSSTR4CYP2C19KMT2A | |
| SCHEMBL30689324 | 0.76 | HCRTR1 (0.47) | KDM4ESSTR4CYP2C19HCRTR1HCRTR2 | |
| SCHEMBL30689381 | 0.75 | HCRTR1 (0.47) | KDM4EALDH1A1SSTR4HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111050765-B | Spiro compounds and methods of making and using the same | H.隆德贝克有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-111050765-A | Spiro compounds and methods of making and using the same | 隆德贝克拉荷亚研究中心有限公司 | 2020-04-21 | — | — | CN | disclosed |