Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FPR3 | P25089 | 6/20 | 0.44 |
| ▸ | FPR2 | P25090 | 6/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24891906 | 0.85 | EPHX2 (0.40) | LMNAPOLBIDO1 | |
| SCHEMBL28294256 | 0.83 | CTSB (0.47) | SMN1; SMN2CTSSCTSKLMNAPOLB | |
| SCHEMBL21437078 | 0.82 | STK17B (0.38) | FPR3FPR2LMNAPOLBIDO1 | |
| SCHEMBL24891861 | 0.81 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL13262888 | 0.80 | AAK1 (0.46) | NPC1RECQLRAB9ASMN1; SMN2FPR3 | |
| SCHEMBL15739717 | 0.77 | NPC1 (0.46) | NPC1RECQLRAB9ASMN1; SMN2FPR3 | |
| SCHEMBL81094 | 0.75 | FPR3 (0.58) | NPC1RECQLRAB9ASMN1; SMN2FPR3 | |
| SCHEMBL31306453 | 0.75 | GSK3B (0.39) | RECQLMAPT | |
| SCHEMBL4901469 | 0.75 | FPR3 (0.55) | NPC1RECQLRAB9ASMN1; SMN2FPR3 | |
| SCHEMBL28654685 | 0.74 | LMNA (0.41) | NPC1RAB9ASMN1; SMN2FPR3FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120429-A | KHK inhibitor | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |