Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29135319 | 0.90 | HRH3 (0.47) | HRH3EGFROPRD1 | |
| SCHEMBL29135318 | 0.87 | HRH3 (0.55) | HRH3CYP11B2CCNT1CDK4CCNA2 | |
| SCHEMBL29135310 | 0.86 | SLC11A2 (0.42) | HRH3DRD2DRD4DRD3OPRD1 | |
| SCHEMBL29135317 | 0.83 | DRD2 (0.44) | HRH3DRD2DRD4DRD3EGFR | |
| SCHEMBL29135315 | 0.83 | HRH3 (0.40) | HRH3EGFROPRD1CCNT1CDK4 | |
| SCHEMBL29135307 | 0.82 | HRH3 (0.52) | HRH3DRD3CYP11B2HDAC4 | |
| SCHEMBL29135312 | 0.82 | TMEM97 (0.41) | HRH3DRD4DRD3CYP11B2 | |
| SCHEMBL29135320 | 0.81 | HRH3 (0.44) | HRH3OPRD1CCNT1CDK4CCNA2 | |
| SCHEMBL29135311 | 0.81 | DRD2 (0.44) | HRH3DRD2DRD4DRD3OPRD1 | |
| SCHEMBL29135321 | 0.81 | HRH3 (0.44) | HRH3CYP3A4CCNT1CDK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989085-B | Aryl lactam ring compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2023-11-24 | — | — | CN | disclosed |