Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | NR1D1 | P20393 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29135318 | 0.89 | HRH3 (0.55) | HRH3MEN1KMT2AKCNH2CCNT1 | |
| SCHEMBL29135316 | 0.85 | HRH3 (0.42) | HRH3ALOX5APFEN1MEN1KMT2A | |
| SCHEMBL29135307 | 0.85 | HRH3 (0.52) | HRH3AKR1C3AKR1C2DHODHKCNH2 | |
| SCHEMBL29135319 | 0.84 | HRH3 (0.47) | HRH3MEN1KMT2AKCNH2 | |
| SCHEMBL29135320 | 0.84 | HRH3 (0.44) | HRH3ALOX5APFEN1MEN1KMT2A | |
| SCHEMBL29135317 | 0.82 | DRD2 (0.44) | HRH3MEN1KMT2ACCNT1CDK4 | |
| SCHEMBL29135306 | 0.81 | HRH3 (0.47) | HRH3CYP3A4PRMT5WDR77CCNT1 | |
| SCHEMBL29135309 | 0.81 | HRH3 (0.55) | HRH3DHODHPRMT5WDR77 | |
| SCHEMBL29135310 | 0.80 | SLC11A2 (0.42) | HRH3KCNH2PRMT5WDR77 | |
| SCHEMBL29135311 | 0.80 | DRD2 (0.44) | HRH3MEN1KMT2AKCNH2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989085-B | Aryl lactam ring compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2023-11-24 | — | — | CN | disclosed |