Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.55 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | SDCBP | O00560 | 1/20 | 0.39 |
| ▸ | SDC2 | P34741 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29135319 | 0.90 | HRH3 (0.47) | HRH3MEN1KMT2AKCNH2 | |
| SCHEMBL29135320 | 0.89 | HRH3 (0.44) | HRH3PTPRCPTPN1MEN1KMT2A | |
| SCHEMBL29135321 | 0.89 | HRH3 (0.44) | HRH3MEN1KMT2AKCNH2CCNT1 | |
| SCHEMBL29135306 | 0.87 | HRH3 (0.47) | HRH3CYP11B2CCNT1CDK4CCNA2 | |
| SCHEMBL29135316 | 0.87 | HRH3 (0.42) | HRH3PTPRCMEN1KMT2AKCNH2 | |
| SCHEMBL29135310 | 0.86 | SLC11A2 (0.42) | HRH3SDCBPSDC2KCNH2 | |
| SCHEMBL29135317 | 0.85 | DRD2 (0.44) | HRH3MEN1KMT2ACCNT1CDK4 | |
| SCHEMBL29135311 | 0.85 | DRD2 (0.44) | HRH3MEN1KMT2AKCNH2CCNT1 | |
| SCHEMBL29135315 | 0.85 | HRH3 (0.40) | HRH3MEN1KMT2AKCNH2CCNT1 | |
| SCHEMBL29135307 | 0.84 | HRH3 (0.52) | HRH3CYP11B1CYP11B2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989085-B | Aryl lactam ring compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2023-11-24 | — | — | CN | disclosed |