Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29135318 | 0.87 | HRH3 (0.55) | HRH3KCNH2PTPRCMEN1KMT2A | |
| SCHEMBL29135309 | 0.86 | HRH3 (0.55) | HRH3THRB | |
| SCHEMBL29135321 | 0.85 | HRH3 (0.44) | HRH3ALOX5APFEN1KCNH2CYP2D6 | |
| SCHEMBL29135319 | 0.84 | HRH3 (0.47) | HRH3KCNH2MEN1KMT2AOPRD1 | |
| SCHEMBL29135308 | 0.83 | HRH3 (0.43) | HRH3ALOX5APFEN1PTPRCMEN1 | |
| SCHEMBL29135320 | 0.81 | HRH3 (0.44) | HRH3ALOX5APFEN1KCNH2PTPRC | |
| SCHEMBL29135307 | 0.80 | HRH3 (0.52) | HRH3KCNH2 | |
| SCHEMBL29135310 | 0.80 | SLC11A2 (0.42) | HRH3KCNH2OPRD1 | |
| SCHEMBL29135317 | 0.79 | DRD2 (0.44) | HRH3SLC6A2SLC6A4MEN1KMT2A | |
| SCHEMBL29135306 | 0.79 | HRH3 (0.47) | HRH3OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989085-B | Aryl lactam ring compound, pharmaceutical composition and application thereof | 安徽医科大学 | 2023-11-24 | — | — | CN | disclosed |