Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912772 | 0.87 | MAPT (0.46) | KCNH2SCN5AEGFRCSF1R | |
| SCHEMBL2913777 | 0.82 | KCNH2 (0.58) | KCNH2SCN5AEGFRCSF1R | |
| SCHEMBL2913426 | 0.81 | CSF1R (0.51) | KCNH2SCN5ACSF1RTLR9TLR7 | |
| SCHEMBL27744484 | 0.80 | KCNH2 (0.49) | KCNH2SCN5AEGFRCSF1R | |
| SCHEMBL2911555 | 0.78 | KCNH2 (0.53) | KCNH2SCN5ACSF1R | |
| SCHEMBL2911700 | 0.76 | KCNH2 (0.51) | KCNH2SCN5AEGFRCSF1R | |
| SCHEMBL2910054 | 0.76 | KCNH2 (0.74) | KCNH2SCN5ACSF1R | |
| SCHEMBL2911203 | 0.75 | CSF1R (0.56) | KCNH2SCN5AEGFRCSF1R | |
| SCHEMBL2904048 | 0.75 | KCNH2 (0.68) | KCNH2SCN5ACSF1R | |
| SCHEMBL2914186 | 0.74 | KCNH2 (0.57) | KCNH2SCN5ACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |