Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.34 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30639338 | 0.85 | GPR119 (0.44) | GPR119MAP4K4MAPTALDH1A1MEN1 | |
| SCHEMBL29138621 | 0.85 | GPR119 (0.44) | GPR119MAP4K4MAPTALDH1A1MEN1 | |
| SCHEMBL29138594 | 0.83 | HCRTR2 (0.36) | MAPTALDH1A1PIK3CDROCK2PRKG1 | |
| SCHEMBL23868538 | 0.73 | ROCK2 (0.50) | GPR119ROCK2PRKG1 | |
| SCHEMBL25124203 | 0.73 | GPR119 (0.41) | GPR119MAP4K4MAPTNPC1HTT | |
| SCHEMBL24700140 | 0.72 | NAMPT (0.46) | GPR119KDM4E | |
| SCHEMBL30426583 | 0.72 | TRPC6 (0.46) | GPR119MAP4K4 | |
| SCHEMBL31061319 | 0.72 | TRPC6 (0.46) | GPR119MAP4K4 | |
| SCHEMBL31105127 | 0.72 | TRPC6 (0.46) | GPR119MAP4K4 | |
| SCHEMBL30639358 | 0.72 | HDAC1 (0.35) | GPR119MAP4K4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023241684-A1 | PDE4B INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-12-21 | — | — | WO | disclosed |
| CN-117247395-A | PDE4B inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-12-19 | — | — | CN | disclosed |