Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29138621 | 1.00 | GPR119 (0.44) | GPR119HSD11B1MEN1KMT2ANPSR1 | |
| SCHEMBL29138587 | 0.85 | GPR119 (0.42) | GPR119MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL29138623 | 0.82 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL31736852 | 0.81 | GPR119 (0.57) | GPR119HSD11B1MEN1KMT2ANPSR1 | |
| SCHEMBL2158777 | 0.81 | MEN1 (0.43) | GPR119MEN1KMT2ANPSR1USP2 | |
| SCHEMBL29138582 | 0.79 | HSD11B1 (0.61) | GPR119HSD11B1MEN1KMT2ANPSR1 | |
| SCHEMBL31728306 | 0.77 | GPR119 (0.37) | GPR119MEN1KMT2ANPSR1USP2 | |
| SCHEMBL3001224 | 0.76 | HSD11B1 (0.47) | GPR119HSD11B1MEN1KMT2ANPSR1 | |
| SCHEMBL23868538 | 0.76 | ROCK2 (0.50) | GPR119HSD11B1LMNA | |
| SCHEMBL25124203 | 0.75 | GPR119 (0.41) | GPR119MEN1KMT2AHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023241683-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND ACTING AS PDE4B INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-12-21 | — | — | WO | disclosed |
| WO-2023241684-A1 | PDE4B INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-12-21 | — | — | WO | disclosed |
| CN-117247395-A | PDE4B inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-117247394-A | Nitrogen-containing heterocycles as PDE4B inhibitors | 武汉人福创新药物研发中心有限公司 | 2023-12-19 | — | — | CN | disclosed |