SCHEMBL29138919

SCHEMBL29138919

Nc1nc2cc(F)[c]cc2c2c1COC2

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29138830 0.82 KDM4E (0.32) KDM4E
SCHEMBL29138823 0.78
SCHEMBL29138890 0.75 PARP1 (0.30)
SCHEMBL29650742 0.75 ACHE (0.47) KDM4E
SCHEMBL29138845 0.72 KDM4E (0.36) KDM4E
SCHEMBL29138860 0.72 KDM4E (0.30) KDM4E
SCHEMBL31353063 0.69 ACHE (0.48)
SCHEMBL24468115 0.69 TBK1 (0.37) KDM4E
SCHEMBL29650675 0.69 TBK1 (0.37) KDM4E
SCHEMBL30661688 0.67 DCPS (0.46) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117986262-A Condensed bicyclic compounds, preparation method and application thereof in medicine 江苏恒瑞医药股份有限公司 2024-05-07 CN disclosed
CN-116888120-A PRMTS inhibitors 美国安进公司 2023-10-13 CN disclosed