SCHEMBL2914112

SCHEMBL2914112

Nc1cc(Br)cn2ccnc12

nearest known ligand 0.65

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.65
NUDT1 P36639 1/20 0.47
HTR2C P28335 2/20 0.37
PIK3R1 P27986 1/20 0.35
PIK3CA P42336 1/20 0.35
DYRK1A Q13627 1/20 0.34
HTR2A P28223 1/20 0.34
APP P05067 1/20 0.33
AURKA O14965 1/20 0.33
ADORA2A P29274 2/20 0.33
SMPD3 Q9NY59 1/20 0.32
PIK3CG P48736 1/20 0.32
CD63 P08962 3/20 0.32
SYK P43405 3/20 0.32
TNKS O95271 1/20 0.31
KEAP1 Q14145 1/20 0.31
HDAC6 Q9UBN7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1576816 0.82 L3MBTL1 (0.67) L3MBTL1NUDT1HTR2CHTR2ATNKS
Hydrochloric Acid SCHEMBL1369700 0.80 L3MBTL1 (0.65) L3MBTL1NUDT1HTR2CHTR2ATNKS
SCHEMBL30871010 0.79 NUDT1 (0.50) L3MBTL1NUDT1HTR2CPIK3R1PIK3CA
SCHEMBL3847774 0.78 L3MBTL1 (0.62) L3MBTL1NUDT1HTR2CHTR2ATNKS
SCHEMBL12144260 0.78 L3MBTL1 (0.62) L3MBTL1NUDT1HTR2CPIK3R1PIK3CA
SCHEMBL15007643 0.78 L3MBTL1 (0.62) L3MBTL1NUDT1HTR2CHTR2AAPP
SCHEMBL1348141 0.78 L3MBTL1 (0.62) L3MBTL1NUDT1HTR2CHTR2ATNKS
SCHEMBL1348114 0.78 L3MBTL1 (1.00) L3MBTL1NUDT1HTR2CHTR2AADORA2A
SCHEMBL14382231 0.78 L3MBTL1 (0.57) L3MBTL1NUDT1HTR2CHTR2ASYK
Hydrochloric Acid SCHEMBL1367208 0.77 L3MBTL1 (0.61) L3MBTL1NUDT1HTR2CPIK3R1PIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118359611-A Imidazo [1,2-a ] pyridine derivative and preparation method and application thereof 郑州大学 2024-07-19 CN claimed
US-20260070902-A1 SULFONYL DERIVATIVES AS CCR6 INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2026-03-12 US disclosed
EP-4694686-A1 FUNGICIDAL COMPOSITIONS Syngenta Crop Protection AG (CH) 2026-02-18 EP disclosed
EP-4630402-A1 SULFONYL DERIVATIVES AS CCR6 INHIBITORS F. Hoffmann-La Roche AG (CH) 2025-10-15 EP disclosed
WO-2024213720-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2024-10-17 WO disclosed
CN-118359611-A Imidazo [1,2-a ] pyridine derivative and preparation method and application thereof 郑州大学 2024-07-19 CN disclosed
WO-2024121013-A1 SULFONYL DERIVATIVES AS CCR6 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2024-06-13 WO disclosed
US-20230219954-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS ASANA BIOSCIENCES, LLC 2023-07-13 US disclosed
US-20230219954-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS ASANA BIOSCIENCES, LLC 2023-07-13 US disclosed
US-20230219954-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS ASANA BIOSCIENCES, LLC 2023-07-13 US disclosed
WO-2009077334-A1 NOVEL IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-06-25 WO disclosed
WO-2009077334-A1 NOVEL IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2009-06-25 WO disclosed
US-7452902-B2 Imidazopyridines as cyclin dependent kinase inhibitors SCHERING CORPORATION (US) 2008-11-18 US disclosed
US-7452902-B2 Imidazopyridines as cyclin dependent kinase inhibitors SCHERING CORPORATION (US) 2008-11-18 US disclosed
EP-1931641-A2 NOVEL 4-CYANO, 4-AMINO, AND 4-AMINOMETHYL DERIVATIVES OF PYRAZOLO[1,5-a]PYRIDINES, PYRAZOLO[1,5-c]PYRIMIDINES AND 2H-INDAZOLE COMPOUNDS AND 5-CYANO, 5-AMINO, AND 5-AMINOMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES, AND IMIDAZO[1,5-a]PYRAZINES COMPOUNDS AS CYCLIN DEPENDENT KINASE INHI SCHERING CORPORATION (US) 2008-06-18 EP disclosed
EP-1539756-B1 IMIDAZOPYRIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS SCHERING CORP (US) 2007-11-14 EP disclosed
US-20070191376-A1 Bicyclic heteroaryl compounds TAKEDA PHARMACEUTICALS U.S.A., INC. 2007-08-16 US disclosed
US-20070066621-A1 Novel 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2h-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors SCHERING CORPORATION 2007-03-22 US disclosed
US-20070066621-A1 Novel 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2h-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors SCHERING CORPORATION 2007-03-22 US disclosed
WO-2007032936-A2 AZAFUSED CYCLIN DEPENDENT KINASE INHIBITORS SCHERING CORPORATION (US) 2007-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219954-A1 P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS P2RX3, P2RX2, P2RX1 L3MBTL1 3916/4885NUDT1 1160/4885HTR2C 283/4885
US-20070191376-A1 Bicyclic heteroaryl compounds CYP3A43, CYP11B2, CYP2F1 L3MBTL1 4087/4885NUDT1 2372/4885HTR2C 161/4885
US-20260070902-A1 SULFONYL DERIVATIVES AS CCR6 INHIBITORS CCR6, CCR1, CCR4 L3MBTL1 1752/4885NUDT1 2665/4885HTR2C 1598/4885
US-20070066621-A1 Novel 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2h-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors CDK4, CDK2, CDK5 L3MBTL1 3797/4885NUDT1 1625/4885HTR2C 378/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.