SCHEMBL29145758

SCHEMBL29145758

Cn1cccc(C2=CCCN(C(=O)O)C2)c1=O

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.34
SOS1 Q07889 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32
MEN1 O00255 1/20 0.32
USP2 O75604 1/20 0.32
TP53 P04637 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
HPGD P15428 1/20 0.32
HIF1A Q16665 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
MYC P01106 2/20 0.31
MAOB P27338 1/20 0.31
ITGB1 P05556 1/20 0.30
ITGA4 P13612 1/20 0.30
ITGB7 P26010 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24710927 0.83 PDK4 (0.45)
SCHEMBL27791722 0.74 CCNT1 (0.39)
SCHEMBL27201488 0.74 KIF11 (0.36) HPGDL3MBTL1
SCHEMBL15140927 0.71 ALDH1A1 (0.42) KMT2AHRH3MEN1HPGDL3MBTL1
SCHEMBL25168915 0.68 GOT1 (0.43)
SCHEMBL27201600 0.67 KDM4E (0.47) L3MBTL1
SCHEMBL29640885 0.66 MYC (0.43) KMT2AMEN1HPGDMYCMAOB
SCHEMBL31450581 0.65 LSS (0.46) MYC
SCHEMBL28985437 0.65 MYC (0.39) KMT2AMEN1MYC
SCHEMBL28365938 0.65 CHEK1 (0.38) MYC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117480162-A Compounds for the treatment or prophylaxis of PRMT5 mediated diseases 阿古诺治疗有限公司 2024-01-30 CN disclosed