Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866002 | 0.77 | — | — | |
| SCHEMBL27685197 | 0.69 | — | — | |
| SCHEMBL9112483 | 0.67 | MGAM (0.36) | TSHR | |
| SCHEMBL3802341 | 0.67 | — | — | |
| SCHEMBL4539743 | 0.67 | MEN1 (0.30) | — | |
| SCHEMBL29269230 | 0.65 | CHRNB2 (0.32) | TSHR | |
| SCHEMBL31356396 | 0.65 | SLC6A3 (0.38) | — | |
| SCHEMBL31356354 | 0.65 | KDM4E (0.41) | — | |
| SCHEMBL8866126 | 0.64 | — | — | |
| SCHEMBL27721708 | 0.63 | PDE4B (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231676-A1 | (E)-N-{3-[1-(8-FLUORO-11H-10-OXA-1-AZA-DIBENZO[A,D]-CYCL0HEPTEN-5YLIDENE)-PROPYL]-PHENYL }-METHYNSULFON AMIDE AS GLUCOCORTICOID RECEPTOR MODULATOR FOR THE TREATMENT OF RHEUMATOID | Eli Lilly & Company (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009089312-A1 | (E)-N-{3- [1-(8-FLUORO-11H-10-OXA-1-AZA-DIBENZO [A,D] CYCL0HEPTEN-5YLIDENE)-PROPYL]-PHENYL }-METHYNSULFON AMIDE AS GLUCOCORTICOID RECEPTOR MODULATOR FOR THE TREATMENT OF RHEUMATOID | ELI LILLY AND COMPANY (US) | 2009-07-16 | — | — | WO | disclosed |
| EP-2043646-A2 | GLUCOCORTICOID RECEPTOR MODULATOR AND METHODS OF USE | ELI LILLY AND COMPANY (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008882-A2 | GLUCOCORTICOID RECEPTOR MODULATOR AND METHODS OF USE | ELI LILLY AND COMPANY (US) | 2008-01-17 | — | — | WO | disclosed |