Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.67 |
| ▸ | CASP3 | P42574 | 3/20 | 0.59 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.58 |
| ▸ | CHUK | O15111 | 1/20 | 0.57 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.57 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.57 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057686 | 0.92 | LMNA (0.60) | LMNATHRBS1PR1CASP3S1PR3 | |
| SCHEMBL26093825 | 0.84 | LMNA (0.70) | LMNATHRBS1PR1CASP3S1PR3 | |
| SCHEMBL26096204 | 0.84 | NR1H4 (0.70) | LMNATHRBS1PR1CASP3S1PR3 | |
| SCHEMBL22925912 | 0.83 | NOTUM (0.61) | LMNATHRBS1PR1CASP3S1PR3 | |
| SCHEMBL27001784 | 0.81 | NPC1 (0.72) | LMNAS1PR1S1PR3NPC1RAB9A | |
| SCHEMBL16592595 | 0.81 | ACHE (0.57) | LMNATHRBNPC1RAB9ATP53 | |
| SCHEMBL13524985 | 0.80 | S1PR1 (1.00) | LMNATHRBS1PR1CASP3S1PR3 | |
| SCHEMBL1259383 | 0.80 | CASP3 (0.57) | LMNATHRBS1PR1CASP3NPC1 | |
| SCHEMBL5208706 | 0.80 | LMNA (0.65) | LMNATHRBS1PR1CASP3S1PR3 | |
| SCHEMBL4744783 | 0.80 | LMNA (0.65) | LMNATHRBS1PR1CASP3S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208955-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | RESEARCH TRIANGLE INSTITUTE | 2024-06-27 | — | — | US | disclosed |
| EP-4304630-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | Research Triangle Institute (US) | 2024-01-17 | — | — | EP | disclosed |
| CN-116963761-A | Small molecule antagonists against relaxin-3/RXFP 3 system | 研究三角协会 | 2023-10-27 | — | — | CN | disclosed |
| WO-2022192126-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | RESEARCH TRIANGLE INSTITUTE (US) | 2022-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240208955-A1 | SMALL MOLECULE ANTAGONISTS FOR THE RELAXIN-3/RXFP3 SYSTEM | RXFP3, RXFP1, RXFP4 | LMNA 3806/4885THRB 152/4885S1PR1 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.