Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.58 |
| ▸ | CASP3 | P42574 | 3/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.50 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29147406 | 0.92 | LMNA (0.70) | LMNATHRBS1PR1CASP3S1PR3 | |
| SCHEMBL3070197 | 0.88 | LMNA (0.62) | LMNATHRBS1PR1CASP3NR1H4 | |
| SCHEMBL13089335 | 0.88 | LMNA (0.62) | LMNATHRBS1PR1CASP3NR1H4 | |
| SCHEMBL3061859 | 0.88 | LMNA (0.62) | LMNATHRBS1PR1CASP3NR1H4 | |
| SCHEMBL35210425 | 0.88 | S1PR1 (0.66) | LMNATHRBS1PR1CASP3S1PR3 | |
| SCHEMBL3053264 | 0.86 | LMNA (0.60) | LMNATHRBS1PR1CASP3NR1H4 | |
| SCHEMBL19968977 | 0.86 | LMNA (0.56) | LMNATHRBS1PR1CASP3NR1H4 | |
| SCHEMBL20968214 | 0.85 | S1PR1 (0.56) | LMNATHRBS1PR1CASP3NR1H4 | |
| SCHEMBL20968198 | 0.85 | S1PR1 (0.55) | LMNATHRBS1PR1CASP3NR1H4 | |
| Hydrochloric Acid SCHEMBL35210424 | 0.85 | LMNA (0.55) | LMNATHRBS1PR1CASP3NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662164-B2 | Non-beta lactam antibiotics | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190127340-A1 | NON-BETA LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC | 2019-05-02 | — | — | US | disclosed |
| US-9045442-B2 | Antibacterial compounds and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045442-B2 | Antibacterial compounds and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045442-B2 | Antibacterial compounds and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-06-02 | — | — | US | disclosed |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-10-14 | — | — | US | disclosed |
| WO-2009082398-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009082398-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009041972-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009041972-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662164-B2 | Non-beta lactam antibiotics | OXA1L, O60361, CUTA | LMNA 1699/4885THRB 1269/4885S1PR1 2372/4885 |
| US-20190127340-A1 | NON-BETA LACTAM ANTIBIOTICS | OXA1L, O60361, CUTA | LMNA 1699/4885THRB 1269/4885S1PR1 2372/4885 |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | SPOUT1, MRPL21, NPEPPS | LMNA 3491/4885THRB 4185/4885S1PR1 3905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.