Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.44 |
| ▸ | CA1 | P00915 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27933679 | 0.92 | CA2 (0.53) | CA2CA1GAAXBP1ATM | |
| SCHEMBL29147480 | 0.90 | CA2 (0.50) | CA2CA1GAAMAPK1MEN1 | |
| SCHEMBL30475458 | 0.90 | CA2 (0.54) | CA2CA1GAAXBP1ATM | |
| SCHEMBL30499378 | 0.90 | ACE2 (0.45) | CA2CA1GAAXBP1ATM | |
| SCHEMBL29013161 | 0.88 | CA2 (0.52) | CA2CA1GAAMAPK1MEN1 | |
| SCHEMBL31480565 | 0.88 | CA2 (0.43) | CA2CA1GAAXBP1ATM | |
| SCHEMBL29264683 | 0.88 | CA2 (0.43) | CA2CA1GAAXBP1ATM | |
| SCHEMBL28718237 | 0.87 | KMT2A (0.39) | CA2CA1GAAMEN1KMT2A | |
| SCHEMBL3243083 | 0.86 | CA1 (0.50) | CA2CA1CTSKACE2 | |
| SCHEMBL7255990 | 0.86 | CA1 (0.50) | CA2CA1CTSKACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964046-B | PLK4 inhibitors and uses thereof | 上海齐鲁制药研究中心有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-116964046-A | PLK4 inhibitors and uses thereof | 上海齐鲁制药研究中心有限公司 | 2023-10-27 | — | — | CN | disclosed |