Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915218 | 0.85 | CYP3A4 (0.40) | CYP3A4CRBNNR1H4ADRB1EPHX2 | |
| SCHEMBL2916163 | 0.85 | CRBN (0.38) | CYP3A4CRBNADRB1 | |
| SCHEMBL2113416 | 0.84 | CYP3A4 (0.56) | CYP3A4CRBNADRB1ABCB1 | |
| SCHEMBL2915057 | 0.82 | CRBN (0.39) | CYP3A4CRBN | |
| SCHEMBL1530670 | 0.82 | CYP3A4 (0.40) | CYP3A4CRBNNR1H4ADRB1ABCB1 | |
| SCHEMBL2910598 | 0.81 | NR1H4 (0.56) | NR1H4CYP26A1 | |
| SCHEMBL2907766 | 0.81 | KMT2A (0.41) | CYP3A4CRBNNR1H4 | |
| SCHEMBL2915217 | 0.81 | CYP3A4 (0.42) | CYP3A4CRBNADRB1ABCB1 | |
| SCHEMBL2915689 | 0.81 | F10 (0.39) | CYP3A4CRBN | |
| SCHEMBL2915916 | 0.81 | CRBN (0.39) | CYP3A4CRBNNR1H4ADRB1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |