Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915358 | 0.90 | ACLY (0.32) | NR3C2 | |
| SCHEMBL2915916 | 0.87 | CRBN (0.39) | CRBNCYP3A4ADRB1NR3C2 | |
| SCHEMBL2914859 | 0.85 | CYP3A4 (0.40) | CRBNCYP3A4ADRB1 | |
| SCHEMBL1530736 | 0.83 | CRBN (0.38) | CRBNCYP3A4ADRB1F10NR3C2 | |
| SCHEMBL2915057 | 0.82 | CRBN (0.39) | CRBNCYP3A4F10 | |
| SCHEMBL2907766 | 0.81 | KMT2A (0.41) | CRBNCYP3A4F10 | |
| SCHEMBL2915689 | 0.81 | F10 (0.39) | CRBNCYP3A4F10 | |
| SCHEMBL2910562 | 0.81 | HPGD (0.41) | CRBNCYP3A4ADRB1F10 | |
| SCHEMBL2915218 | 0.80 | CYP3A4 (0.40) | CRBNCYP3A4ADRB1 | |
| SCHEMBL2913875 | 0.80 | F10 (0.37) | CRBNF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |